Super Refined™ excipients for oral drug delivery
Our proprietary Super Refining process yields highly purified excipients that can maximise drug product value and are indicated to stabilise, solubilise and optimise the active ingredients in the formulation.Oral drug value:
- Enhanced drug performance and stability
- Improved shelf life
- Increased patient compliance
- Improved bioavailability
- Decreased formulation development time
- Decreased time to market.
Benefits and features of high purity excipients for oral drug delivery:
Improved API stability
Stabilisation of an API is crucial to successful drug development. As API degradation can be initiated and accelerated by impurities that can be introduced by excipients in the formulation, carefully selecting the right oral excipient can be essential to formulation success.
Increased gelatine capsule stability
Over time, the impurities found in commonly used solvents and fillers in gelatine capsules can preferentially absorb moisture from the gelatine shell. The moisture absorption can cause the gelatine to crosslink which, ultimately, cause the capsule to harden. The hardening of the capsule can result in either cracking or longer disintegration times leading to unacceptable drug efficacy.
Improved taste impact
The impact of an excipient on the taste of an oral drug can significantly affect patient compliance and repeat purchase.
Reduced colour impurities
The Super Refining process yields a highly purified excipient with a reduction in both colour and overall impurity levels. The purification of oral excipients yields improved drug appearance as well as improved stability of the excipient; the API and drug formulation.
Super Refined™ pharmaceutical excipients

Oral excipient offering:
Croda offers a breadth of high purity ingredients that lend themselves well to solubilising a poorly water soluble drug, stabilising it once it’s in solution, and creating SEDDS and SMEDDS formulations. The list is constantly growing, and we strive to work with our customers to provide them with a solution they need!

Crodasol™ HS HP
Crodasol HS HP is a high purity nonionic surfactant which provides excellent solubilisation properties. Compliant to the PhEur monograph, it is a mixture of monoesters and diesters of...

Croduret™ 40
Crodurets are vegetable-derived nonionic surfactants that differ in their degrees of ethoxylation. Widely used in a variety of oral formulations, they are virtually tasteless solubilisers for vitamins...

Super Refined™ CCMG 400
Super Refined CCMG 400 is a multi-compendial, high purity mixture of caprylocaproyl polyoxylglycerides. It is ideal for use as a surfactant or co-solvent in self-emulsifying drug delivery systems...

Super Refined™ GMCC
Super Refined™ GMCC is a high purity mixture of monoglycerides and diglycerides of caprylic and capric acids. It is used to produce stable emulsions and to modify viscosity. It functions as a...
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Super Refined™ L18 POG
Super Refined™ L18 POG is a high purity mixture of mono-, di-, and triesters of glycerol, and mono- and diesters of polyethylene glycols, with the predominant fatty acid concentration stemming from...
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Super Refined™ O18 POG
Super Refined™ O18 POG is a high purity mixture of mono-, di-, and triesters of glycerol, and mono- and diesters of polyethylene glycols with the predominant fatty acid concentration stemming from...

Super Refined™ P35 Castor Oil
Super Refined P35 Castor Oil is a multi-compendial, high purity castor oil derivative, resulting from the reaction of glycerol ricinoleate and 35 mols of ethylene oxide. It is intended for use in...
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Super Refined™ PGML
Super Refined™ PGML is a high purity mixture of propylene glycol and esters of lauric (C12) acid. More specifically, as part of the Type II classification, it has at least a 90% concentration of...

Super Refined™ Polysorbate 20
Super Refining removes impurities, preventing adverse interactions with APIs and enhancing the stability of pharmaceutical formulations. Super Refined Polysorbates offer the complete solution when...

Super Refined™ Polysorbate 60
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes impurities (including primary and...

Super Refined™ Polysorbate 80
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes impurities (including primary and...
Croda offers a breadth of high purity ingredients that lend themselves well to solubilising a poorly water soluble drug, stabilising it once it’s in solution, and creating SEDDS and SMEDDS formulations. The list is constantly growing, and we strive to work with our customers to provide them with a solution they need!

Super Refined™ DEGEE
Super Refined DEGEE is a multi-compendial, high purity glycol ether. This clear, colourless liquid demonstrates outstanding permeation enhancement and improved delivery and bioavailability for topical...

Super Refined™ PEG 300
The Super Refined PEG range is a series of Super Refined polyethylene glycols, offering pharmaceutical formulators highly purified hydrophilic excipients that can enhance active and formulation...

Super Refined™ PEG 400
The Super Refined PEG range is a series of Super Refined polyethylene glycols, offering pharmaceutical formulators highly purified hydrophilic excipients that can enhance active and formulation...

Super Refined™ PEG 600
Super Refined PEGs are solvents for use with the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes polar impurities (including primary and...

Super Refined™ Propylene Glycol
Super Refined Propylene Glycol is a highly purified propylene glycol that has a wide use in pharmaceutical formulations as a solvent, stablilising agent, water-miscible cosolvent, plasticiser,...

Super Refined™ DMI
High purity liquid for use with poorly soluble hydrophilic and hydrophobic actives. Enhances the formulation and API stability in transdermal delivery systems. Recommended topical usage levels of...
Croda offers a breadth of high purity ingredients that lend themselves well to solubilising a poorly water soluble drug, stabilising it once it’s in solution, and creating SEDDS and SMEDDS formulations. The list is constantly growing, and we strive to work with our customers to provide them with a solution they need!
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Span™ 20 HP
A high purity version of Span 20 tested against the USP/NF, PhEur and JPE monographs. This HP grade offers lower moisture levels as well as lower peroxide and acid values. Recommended use level is 0...
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Span™ 80 HP
A high purity version of Span 80 tested against both PhEur and USP monographs. This HP grade offers lower moisture levels as well as lower peroxide and acid values. Recommended topical usage levels of...
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Cithrol™ GMO HP
High purity oleic acid grade with a GMO content of 92% minimum. Offers controlled drug release and enhances active bioavailability. Membrane penetration enhancer. W/O emulsifier and O/W emulsion...
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Super Refined™ excipients
We have a large variety of products, ranging from various polysorbates, polyethylene glycols (PEG), esters, vegetable oils, and more.