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Pharma

High purity excipients for oral drug delivery

Oral drug development of both new and existing chemical entities often face numerous challenges including poor solubility, formulation instability and ineffective drug delivery. Regardless of the challenge, the ultimate goal is to create successful drug products with shortened development timelines. The selection of the right oral excipient during early phase development is critical to achieve this goal.

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Super Refined™ excipients for oral drug delivery

Our proprietary Super Refining process yields highly purified excipients that can maximise drug product value and are indicated to stabilise, solubilise and optimise the active ingredients in the formulation.

Oral drug value:

  • Enhanced drug performance and stability
  • Improved shelf life
  • Increased patient compliance
  • Improved bioavailability
  • Decreased formulation development time
  • Decreased time to market.

Benefits and features of high purity excipients for oral drug delivery: 

Improved API stability 

Stabilisation of an API is crucial to successful drug development. As API degradation can be initiated and accelerated by impurities that can be introduced by excipients in the formulation, carefully selecting the right oral excipient can be essential to formulation success.

Increased gelatine capsule stability

Over time, the impurities found in commonly used solvents and fillers in gelatine capsules can preferentially absorb moisture from the gelatine shell. The moisture absorption can cause the gelatine to crosslink which, ultimately, cause the capsule to harden. The hardening of the capsule can result in either cracking or longer disintegration times leading to unacceptable drug efficacy.

Improved taste impact

The impact of an excipient on the taste of an oral drug can significantly affect patient compliance and repeat purchase.

Reduced colour impurities

The Super Refining process yields a highly purified excipient with a reduction in both colour and overall impurity levels. The purification of oral excipients yields improved drug appearance as well as improved stability of the excipient; the API and drug formulation. 

Super Refined pharmaceutical excipients

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Excipientes Super Refined™

Nossa linha de excipientes Super Refined™ garante que suas formulações sejam estáveis, eficazes e consistentes.

Creation of SEDDS and SMEDDS

Self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS) are lipid-based formulations that aim to deliver hydrophobic drugs that typically are associated with poor water solubility and low bioavilability.

Low moisture

Low peroxide levels

Multicompendial

USP/NF, Ph.Eur., JPE and ChP
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Oral excipient offering:

Recommended high purity components for SEDDS and SMEDDS development:

Super Refined Castor Oil

Super Refined™ Castor Oil

Super Refined Castor Oil é uma versão de alta pureza de óleo de rícino obtidonaturalmente; um excipiente farmacêutico bastante útil devido a seu alto grau defuncionalidade. No entanto, essa...
Super Refined Cottonseed

Super Refined™ Cottonseed

Triglicéridos derivados do milho que foram purificados para produzir um lipídio neutro não polar claro e inodoro com um índice de peróxido baixo. O processo exclusivo de Super Refining remove as...
Super Refined Oleic Acid

Super Refined™ Oleic Acid

Super Refined Oleic Acid é um ácido oleico altamente purificado apropriado para uso em aplicações tópicas, orais e nasais. Age como um solubilizante, agente emulsificante e potencializador de...
Super Refined Peanut Oil

Super Refined™ Peanut Oil

Triglicerideo derivado de amendoim que foi purificado para produzir um lipídio neutro não polar claro e inodoro com um índice de peróxido baixo  . O processo exclusivo de Super Refining remove as...
Super Refined Sesame Oil

Super Refined™ Sesame Oil

Triglicéridos derivados de sésamo que foram purificados para produzir um lipídio claro, neutro não polar e inodoro com um índice de peróxido baixo. O processo Super Refining remove impurezas polares...
Super Refined Corn Oil

Super Refined™ Corn Oil

Triglicéridos derivados do milho que foram purificados para produzir um lipídio neutro não polar claro e inodoro com um índice de peróxido baixo. O processo exclusivo de Super Refining remove as...
Super Refined Olive Oil

Super Refined™ Olive Oil

Triglicerídeo derivado da oliva que passou pelo processo Super Refining para remover impurezas polares sem alterar sua composição química. Isso reduz o potencial para interações adversas entre o...
Super Refined Soybean Oil

Super Refined™ Soybean Oil

Triglicéridos derivados de soja que foram purificados para produzir um lipídio claro, neutro não polar e inodoro com um índice de peróxido baixo. O processo Super Refining remove impurezas polares...

Explore our product offering

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Super Refined™ excipients

Super Refined excipients are stripped of a number of oxidative impurities, such as peroxides, aldehydes, and catalyst residues. The removal of these problematic species helps to reduce negative API & excipient interactions, maintaining both the stability of the drug and the final formulation. In addition, the removal of these impurities can minimise cellular irritation, reduce taste impact, and potentially decrease allergenicity. 

We have a large variety of products, ranging from various polysorbates, polyethylene glycols (PEG), esters, vegetable oils, and more. 
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