High purity excipients for oral drug delivery

Super Refined™ excipients for oral drug delivery

Oral drug value:

• Enhanced drug performance and stability
• Improved shelf life
• Increased patient compliance
• Improved bioavailability
• Decreased formulation development time
• Decreased time to market.

Benefits and features of high purity excipients for oral drug delivery: 

Improved API stability 

Stabilisation of an API is crucial to successful drug development. As API degradation can be initiated and accelerated by impurities that can be introduced by excipients in the formulation, carefully selecting the right oral excipient can be essential to formulation success.

Increased gelatine capsule stability

Over time, the impurities found in commonly used solvents and fillers in gelatine capsules can preferentially absorb moisture from the gelatine shell. The moisture absorption can cause the gelatine to crosslink which, ultimately, cause the capsule to harden. The hardening of the capsule can result in either cracking or longer disintegration times leading to unacceptable drug efficacy.

Improved taste impact

The impact of an excipient on the taste of an oral drug can significantly affect patient compliance and repeat purchase.

Reduced colour impurities

The Super Refining process yields a highly purified excipient with a reduction in both colour and overall impurity levels. The purification of oral excipients yields improved drug appearance as well as improved stability of the excipient; the API and drug formulation.