Lipid based drug delivery systems
We offer a wide range of lipids and lipid derivatives to meet the needs of our customers. Additionally, we are proud to extend our product offering to include Avanti Polar Lipids’ extensive portfolio of high purity and specialized lipids and adjuvants, furthering our commitment to bringing innovation in the hands of our customers to help them in getting groundbreaking therapies to market.
As the Lipid Technology segment of the Croda Pharma business, Avanti is primarily focused on developing innovative lipid-based products to address specific medical challenges that are not resolved by current technology or drug products.
Curious about how our lipid technology can aid your drug delivery research?
For over 30 years, Avanti has been working with the pharmaceutical and diagnostic industry to provide solutions that save or improve lives. We were integrally involved in the development of liposomal-based drug delivery systems and over the past decade we have concentrated on developing lipid components used in Lipid Nanoparticle (LNP) delivery technology to solve the stability and delivery issues associated with mRNA-based vaccines and therapeutics.
LNPs are lipid-based drug delivery systems that carry nucleic acid material. These systems primarily rely on four lipid components: a PEG lipid, amino (cationic) lipid, structural lipid, and cholesterol.
The cationic lipids are used to sequester the genetic material through a charge-charge interaction. This is encapsulated by the structural lipid and functionalized on the exterior with PEG lipids. Genetic material is highly susceptible to RNAse activity but the LNP protects the genetic material from degradation. The LNP also allows the genetic material to gain access to the cell and once inside, to be released. This allows the cellular machinery to translate the delivered genetic material into a cellular response.
When conducting LNP formulation research there are many important factors to consider including size and shape, surface charge, hydrophobicity, and surface functionalization. Avanti offers a wide variety of cGMP manufactured lipids that will allow you to perfectly tailor your drug delivery systems. As always, these lipids are manufactured to meet the Avanti purity standard of 99% purity.