Super Refined™ Polysorbate 20

Super Refined™ Polysorbate 20 is an excipient that can solubilise and stabilise even the most sensitive active pharmaceutical ingredients (APIs) in drug formulations. The Super Refining process removes polar impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition. This makes Super Refined™ Polysorbate 20 suitable for use in a wide range of formulations across human and veterinary drug development

Benefits of Super Refined™ Polysorbate 20

Polysorbates are susceptible to degradation from oxidation and hydrolysis, which can influence the stability of the APIs in drug formulations (Brovč et al., 2020). Croda Pharma’s Super Refined™ Polysorbate 20 goes through a purification process that removes polar impurities, including primary and secondary oxidation products. This helps to reduce negative API interaction and degradation.

Super Refined™ Polysorbate 20 also helps to prevent protein aggregation and reduces potential for cellular irritation. These benefits make it ideal for use in parenteral and ophthalmic applications. The Super Refined™ manufacturing process also ensures high batch-to-batch consistency which allows for a predictable formulation.

Chemical description

Polysorbate 20

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