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Pharma

High purity excipients for oral drug delivery

Oral drug development of both new and existing chemical entities often face numerous challenges including poor solubility, formulation instability and ineffective drug delivery. Regardless of the challenge, the ultimate goal is to create successful drug products with shortened development timelines. The selection of the right oral excipient during early phase development is critical to achieve this goal.

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Super Refined™ excipients for oral drug delivery

Our proprietary Super Refining process yields highly purified excipients that can maximise drug product value and are indicated to stabilise, solubilise and optimise the active ingredients in the formulation.

Oral drug value:

  • Enhanced drug performance and stability
  • Improved shelf life
  • Increased patient compliance
  • Improved bioavailability
  • Decreased formulation development time
  • Decreased time to market.

Benefits and features of high purity excipients for oral drug delivery: 

Improved API stability 

Stabilisation of an API is crucial to successful drug development. As API degradation can be initiated and accelerated by impurities that can be introduced by excipients in the formulation, carefully selecting the right oral excipient can be essential to formulation success.

Increased gelatine capsule stability

Over time, the impurities found in commonly used solvents and fillers in gelatine capsules can preferentially absorb moisture from the gelatine shell. The moisture absorption can cause the gelatine to crosslink which, ultimately, cause the capsule to harden. The hardening of the capsule can result in either cracking or longer disintegration times leading to unacceptable drug efficacy.

Improved taste impact

The impact of an excipient on the taste of an oral drug can significantly affect patient compliance and repeat purchase.

Reduced colour impurities

The Super Refining process yields a highly purified excipient with a reduction in both colour and overall impurity levels. The purification of oral excipients yields improved drug appearance as well as improved stability of the excipient; the API and drug formulation. 

Super Refined™ pharmaceutical excipients

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Excipientes Super Refined™

Nuestra línea de excipientes Super Refined™ asegura que sus formulaciones sean estables, efectivas y consistentes.

Creation of SEDDS and SMEDDS

Self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS) are lipid-based formulations that aim to deliver hydrophobic drugs that typically are associated with poor water solubility and low bioavilability.

Low moisture

Low peroxide levels

Multicompendial

USP/NF, Ph.Eur., JPE and ChP
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Oral excipient offering:

Recommended high purity components for SEDDS and SMEDDS development:

Super Refined Castor Oil

Super Refined™ Castor Oil

El aceite de ricino refinado es una versión altamente purificada de aceite de ricino derivado naturalmente con un alto grado de funcionalidad, haciéndolo un excipiente extremadamente útil. Sin embargo...
Super Refined Cottonseed

Super Refined™ Cottonseed

Triglicérido derivado de semilla de algodón que se ha purificado para producir un lıpido no polar neutro, blanco, inodoro y con un bajo valor de peróxido. El proceso patentado Super Refining elimina...
Super Refined Oleic Acid

Super Refined™ Oleic Acid

Acido Oleico Super Refined  es un ácido oleico altamente purificado, adecuado para su uso en aplicaciones de dosis tópica, oral y nasal, que actúa como un agente solubilizante, emulsionante y...
Super Refined Peanut Oil

Super Refined™ Peanut Oil

Triglicérido derivado de Cacahuete que ha sido purificado para producir un lıpido no polar neutro, blanco, inodoro y con un bajo valor de peróxido. El proceso patentado de Super Refining elimina las...
Super Refined Sesame Oil

Super Refined™ Sesame Oil

Triglicérido derivado de sésamo que ha sido purificado para producir un líquido lipídico no polar, blanco, inodoro, con un bajo índice de peróxido.
Super Refined Corn Oil

Super Refined™ Corn Oil

Triglicérido derivado del maíz que ha sido purificado para producir un lıpido no polar blanco, inodoro, neutro y con un bajo valor de peróxido. El proceso patentado Super Refining elimina las...
Super Refined Olive Oil

Super Refined™ Olive Oil

Triglicérido derivado de Oliva que ha sido Super Refinado para eliminar las impurezas polares sin alterar la composición química. Esto reduce el potencial de interacciones adversas entre el excipiente...
Super Refined Soybean Oil

Super Refined™ Soybean Oil

Triglicérido derivado de la soja que ha sido purificado para producir un lípido no polar neutro, blanco, inodoro, con un bajo índice de peróxido. El Super Refining elimina las impurezas polares...

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Super Refined™ excipients

Super Refined excipients are stripped of a number of oxidative impurities, such as peroxides, aldehydes, and catalyst residues. The removal of these problematic species helps to reduce negative API & excipient interactions, maintaining both the stability of the drug and the final formulation. In addition, the removal of these impurities can minimise cellular irritation, reduce taste impact, and potentially decrease allergenicity. 

We have a large variety of products, ranging from various polysorbates, polyethylene glycols (PEG), esters, vegetable oils, and more. 
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