
Several excipients in combination were required to achieve high drug solubility for a long lasting effect, the drug was prone to oxidation in excipients and some key solubilising excipients have a strong unpleasant odour.
- Selection of patch design
- Solubility between API and excipient blend
- Physical and chemical compatibility between API and excipient blend
- Impact of excipient blend on skin permeation
- Impact of excipient blend on non-drug substance related impurities
- Impact of excipients on adherence for duration of wear period.
- Excellent API solubility
- Excellent oxidation stability
- Excellent hydrolysis stability
- Low cellular irritation
- Better skin permeation enhancement
- Reduced odour impact.
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Several excipients in combination were required to achieve high drug solubility for a long lasting effect, the drug was prone to oxidation in excipients and some key solubilising excipients have a strong unpleasant odour.
Super Refined™ PEG 400, Super Refined Castor Oil and Crodamol™ DA Pharma offer the API solubility required when combined. Crodamol DA Pharma is low in odour compared to competitor diisopropyl adipate. Super Refined Polysorbate 80 helps compatibilise the formulation excipients. Our Super Refined excipients and Crodamol DA Pharma have superior stability, protecting the formulation from drug degradation.
Pack claims unlocked: - 1: Odourless, 2: Fast acting pain relief, 3: Less frequent application.