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Introducing our Adjuvant Systems Platform

Our next instalment of the Croda Pharma blog looks at our Adjuvant Systems platform. Keep reading to learn more about how we can support both your current and future needs for vaccine formulations.

Leveraging a history of developing adjuvants since 1939, we pride ourselves in being an innovative and reliable partner for our customers. For this reason, we are a trusted leader with widely recognised brands in the vaccine industry, such as Alhydrogel™, Adju-Phos™ and Quil-A™.

Your trusted adjuvant partner, today and tomorrow

With over 80 years of experience our scientists deliver high quality adjuvants to meet your vaccine formulation needs today. Beyond today we want to meet your formulation needs of the future. Our extensive expertise in immunology and formulation of adjuvant systems means we can partner with you to develop the next generation of vaccines, adapting to your requirements. We use our manufacturing experience to turn novel technologies into commercial GMP products, driven by our purpose to use ‘smart science to improve lives™’

Our adjuvant portfolio 

We offer a diverse portfolio of technologies at the highest of production standards. With extensive experience in cGMP manufacturing, we manufacture high quality mineral adjuvants, and saponins. We are constantly working to expand our adjuvant offering to meet market needs and enable the fight against pathogens and enable the development of modern therapeutic vaccines also.

Our adjuvant development pipeline - Cationic Adjuvant Formulation CAF®

Our adjuvant offering has expanded to offer two CAF adjuvants CAF01 and CAF09b, both showing promise for use in novel vaccines in early life and cancer immunotherapy trials respectively. If you would like to learn more about CAF or any of our other adjuvant offering contact us here.
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This pipeline technology, CAF®, aims to address the weak cell mediated immunity response induced by vaccine antigens. The CAF technology platform is range of new, patented cell mediated immunity inducing cationic liposomal adjuvants.

The CAF range has a number of benefits including:

 

Cationic adjuvant formulation image

- Ensure a strong co-localisation between the antigen and adjuvant – key for inducing T-cell immunity

- Prolonged exposure of the antigen to the immune system – improving the memory profiles of the induced         immunity

- Initial activation of the immune system is very localised to the injection site – reducing systemic side effects      associated with vaccinations e.g. fever and system pain

 

If you would like to learn more about immunostimulation and where adjuvant technology is headed listen to our webinar with Dr. Dennis Christensen on demand here.

Empowering the development of tomorrow's vaccines

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Adjuvant systems

Adjuvant Systems

Your partner for modern vaccine development. Our unique GMP portfolio and outstanding expertise can meet your adjuvant needs. Collaborate with our scientists to create the vaccines of tomorrow.
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Sustainable Squalene

Sustainable Squalene

Our sustainable Squalene is based on cutting-edge technology using synthetic biology to obtain squalene from a fermentation process.
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PHAD

PHAD™ (MPLA Analogue)

Versatile and effective, PHAD acts as a TLR4 agonist to activate proinflammatory cytokines and antigen-specific effector cells. PHAD is the first synthetic analogue of monophosphoryl lipid A (MPLA), also...
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CAF01

CAF01®

Part of our new generation of adjuvants, CAF01 is a liposomal adjuvant formulation that offers excellent long-term stability and drives both humoral and cellular immune responses.
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CAF09b

CAF09b®

A novel liposomal adjuvant used in cancer immunotherapy trials, CAF09b has the capacity to facilitate the production of CD8+ T-cells.
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Adju-Phos

Adju-Phos™

Well-established as a common component in a variety of vaccines, Adju-Phos is an aluminium-based adjuvant that induces strong Th2 immune responses.
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3D(6-acyl)-PHAD

3D(6-acyl)-PHAD™

Immunostimulatory and highly purified, 3D(6-acyl)-PHAD activates TLR4 to induce proinflammatory cytokines and T-cells. 3D(6-acyl)-PHAD is a synthetically produced structural analogue of monophosphoryl...
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3D-PHAD

3D-PHAD™

Highly pure, safe, and chemically stable, 3D-PHAD stimulates the immune system through the activation of TLR4, leading to the production of proinflammatory cytokines, CD4+ and CD8+ T-cells. 3D-PHAD is...
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Alhydrogel

Alhydrogel™

One of the most widely used vaccine adjuvants, Alhydrogel is an aluminium-based adjuvant used in clinically-approved vaccines that can elicit effective Th2 immune responses.
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QS 21

QS 21

A powerful immunostimulatory saponin that acts as a potent vaccine adjuvant, QS 21 can stimulate both cell-mediated (Th1) and humoral (Th2) immune responses
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Quil-A

Quil-A™

A versatile immunostimulatory saponin that’s widely used as a potent veterinary adjuvant, Quil-A can work against both intra- and extra-cellular pathogens, stimulating innate and Th-mediated adaptive immune...
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Published by
  • Angela Kleiner Marketing Director - Adjuvant Systems & Veterinary Health
  • Catherine Weaver Graduate Trainee, Medical Genetics BSC, Cancer Molecular Pathology MSc
Published on:
Thursday 2nd February 2023
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Croda Pharma is a world leader in pharmaceutical excipients, vaccine adjuvants and innovative lipids for human and veterinary applications. Get in touch with our experts today to get your next project started.
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