Smart science to improve lives™

Sustainably sourced Squalene

Add to favourites
A key component in emulsion adjuvants, the triterpenoid squalene is the most used oil in adjuvants for human vaccines. Squalene-based emulsion adjuvants induce a strong innate immune response and are characterised by an established safety profile and high tolerance in vulnerable people. 

Squalene has traditionally been sourced from shark liver oil which represents an ecological threat. This led to the search for sustainable alternatives with equivalent properties suitable for vaccine development.

Our sustainably produced Squalene is based on cutting-edge technology using synthetic biology to obtain squalene from a fermentation process. The final purification step turns it into a pharmaceutical grade Squalene suitable for vaccine formulations. 

Such sustainably sourced Squalene offers multiple benefits:

The highly purified Squalene complies with the monograph specifications of the Ph. Eur. monograph 2805 for squalene used as an adjuvant in vaccines. Its purity exceeds the minimum requirements of the Ph. Eur. monograph with a purity of at least 99% and meets the stringent requirements of the vaccine industry. 

It is molecularly identical to shark-derived squalene with demonstrated stability in emulsion adjuvants.

The sustainable production process ensures a scalable and secure supply chain and helps to protect shark populations which play a key role in maintaining marine ecosystems.

Squalene-based emulsions are used in licensed seasonal and pandemic influenza vaccines. Furthermore, there are clinical development projects for prophylactic vaccines ongoing, such as those against tuberculosis, shingles, schistosomiasis, HIV and other severe diseases, combining squalene with a TLR4 agonist in their emulsion adjuvant.

Our sustainably sourced Squalene is currently available for research use only.  

Product details

Chemical group

  • Natural lipid belonging to the terpenoid family

Administration route

  • Vaccine adjuvant

Market application

  • Human vaccines
  • Veterinary vaccines


  • Component in emulsion vaccine adjuvants

Physical form

  • Liquid

Frequently asked questions