Super Refined™ excipients for parenteral drug delivery
Parenteral formulation frequently faces limitations associated with drug stability and poor solubility. Drug compatibility and the minimum concentration of drug required to produce the targeted pharmacological effect are key to excipient selection.
Your partner for parenteral formulations:
- Access specialised technical support to navigate and address your formulation challenges
- Explore our extensive offering of high purity, multi-compendial excipients listed by the FDA Inactive Ingredients Database as suitable for parenteral administration
- Our Super RefinedTM products add value to your parenteral drug formulations, reducing API degradation and aiding in successful formulation development.
Reduced API costs for parenteral formulations
Our technical experts have reformulated a range of APIs with our Super Refined excipients, demonstrating a significantly higher percentage of API is retained over time when compared to formulation with standard pharmaceutical grade excipients. Reducing the degradation of your API in formulation lowers your API costs due to a decrease in the minimum efficient concentration required to produce the desired pharmacological effect over the shelf life of your product.
By reducing API degradation, less API is required per dose to reach the efficient concentration to produce the desired pharmacological effect. This not only improves the shelf life of your product but also reduces API costs.
Improving product safety profiles for parenteral delivery
The removal of polar impurities reduces API/excipient interactions, minimising the presence of API degradation products.
Lengthening product shelf lives
Super Refined excipients have been demonstrated to outperform their standard compendial grade counterparts. Our excipients extend the stability of APIs over significantly longer time periods and reduce API oxidation potential – increasing drug stability.
Improving patient comfort for parenteral delivery
Our Super Refined products improve patient comfort through minimising cellular irritation and allergenic reaction potential.
Injectable delivery of small molecules
Discover our vast portfolio of parenteral offerings used specifically in the injectable delivery of small molecules.
One category of our injectable excipient portfolio includes lipids. Lipid excipients play a pivotal role in enhancing the parenteral delivery of small molecule APIs by facilitating the formation of liposomes. Liposomes provide a stable and biocompatible carrier system for the encapsulation and solubilization of both hydrophobic and hydrophilic drug compounds. This unique capability not only improves the drug's bioavailability but also ensures a controlled and sustained release, optimizing therapeutic outcomes.
Liposomal drug delivery has shown proven efficacy in various small molecule applications, including pain management drugs as well as cancer therapies. The ability of liposomes to encapsulate drugs makes them an ideal choice for targeted delivery, addressing the specific challenges associated with these critical therapeutic areas. Our dedicated focus on developing cutting-edge lipid excipients underscores our commitment to advancing the field of injectable drug delivery, providing pharmaceutical developers with reliable solutions for formulating next-generation small molecule drugs.
Parenteral excipient offering:
20 items available
Super Refined™ Polysorbate 80
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral.
Super Refining removes impurities (including primary and secondary...
Super Refined™ Polysorbate 20
Super Refining removes impurities, preventing adverse interactions with APIs and enhancing the stability of pharmaceutical formulations. Super Refined Polysorbates offer the complete solution when formulating...
Super Refined™ Propylene Glycol
Super Refined Propylene Glycol is a highly purified propylene glycol that has a wide use in pharmaceutical formulations as a solvent, stablilising agent, water-miscible cosolvent, plasticiser, humectant,...
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Super Refined™ Castor Oil
Super Refined Castor Oil is a highly purified version of naturally derived castor oil, which has a high degree of functionality, making it an extremely useful excipient. However, this increased functionality...
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Super Refined™ Peanut Oil
Peanut-derived triglyceride, that has been Super Refined™ to remove impurities. Purified to yield a water-white, odourless, neutral non-polar lipid with a low peroxide value. Used as an excipient in pharmaceutical...
Super Refined™ PEG 300
The Super Refined PEG range is a series of Super Refined polyethylene glycols, offering pharmaceutical formulators highly purified hydrophilic excipients that can enhance active and formulation stability....
Super Refined™ PEG 400
The Super Refined PEG range is a series of Super Refined polyethylene glycols, offering pharmaceutical formulators highly purified hydrophilic excipients that can enhance active and formulation stability....
Super Refined™ PEG 600
Super Refined PEGs are solvents for use with the most sensitive active ingredients across dosage forms including injectable and oral.
Super Refining removes polar impurities (including primary and secondary...
Super Refined™ Oleic Acid
Highly purified oleic acid is used as a co-emulsifier in topical pharmaceutical formulations. Ideal for nasal drug delivery and as a penetration enhancer in transdermal formulations. In addition, it can...
Super Refined™ Corn Oil
Corn-derived triglyceride that has been Super Refined™ to remove impurities. Purified to yield a water-white, odourless, neutral non-polar lipid with a low peroxide value. Ideal for use in pharmaceutical...
Super Refined™ Polysorbate 60
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral.
Super Refining removes impurities (including primary and secondary...
Super Refined™ Soybean Oil
Soy-derived triglyceride that has been Super Refined™ to remove impurities. Purified to yield a water-white, odourless, neutral non-polar lipid with a low peroxide value. Used in pharmaceutical preparations...
Super Refined™ GTCC
Super Refined GTCC is a high purity mixed ester consisting primarily of the saturated fatty acids caprylic (C8) and capric (C10) acid. Products of this type are commonly referred to as medium chain triglycerides...
Super Refined™ Cottonseed
Cottonseed-derived triglyceride that has been Super Refined™ to remove impurities.
Super Refined™ P35 Castor Oil
Super Refined P35 Castor Oil is a multi-compendial, high purity castor oil derivative, resulting from the reaction of glycerol ricinoleate and 35 mols of ethylene oxide. It is intended for use in parenteral,...
Tween™ 20 HP
Tween 20 HP is a low moisture, low peroxide, high performance version designed for parenteral use. Tween 20 HP is an excellent O/W emulsifier, solubiliser and wetting agent. Recommended topical usage levels...
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Tween™ 80 HP
Tween 80 HP is a low moisture, low peroxide, high performance grade designed for parenteral use. Tween 80 HP works as an O/W emulsifier, solubiliser and wetting agent. This grade exceeds standards set...
Super Refined™ Polysorbate 80 POA
Looking for ChP compliance? Super Refined Polysorbate 80 POA is a high purity polysorbate 80 that has been created to meet the tight specification of the Chinese Pharmacopeia for polysorbate 80 injection.
Super Refined™ Sesame Oil
Sesame-derived triglyceride that has been Super Refined™ to remove impurities. Purified to yield a water-white, odourless, neutral non-polar lipid with a low peroxide value. Its major use is as a solvent...
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Span™ 20 HP
A high purity version of Span 20 tested against the USP/NF, PhEur and JPE monographs. This HP grade offers lower moisture levels as well as lower peroxide and acid values. Recommended use level is 0....
Vaccine adjuvants
Our range of vaccine adjuvants can support your injectable formulation
Adjuvants are used in vaccines to accelerate, prolong, or enhance antigen-specific immune responses. Adjuvants help to raise an early, long-lasting and efficient immune response, increasing vaccine efficacy and providing a high degree of protection against the disease against which you are vaccinating.
Adjuvants enable you to reach the same level of immune protecting protection with fewer injections or a lower dose than when vaccinating with the non-adjuvanted antigen alone. (This can result in better patient compliance – less side effects/more likely to finish course if fewer vaccines are required).
Super Refined™ excipients
Super Refined excipients are stripped of a number of oxidative impurities, such as peroxides, aldehydes, and catalyst residues. The removal of these problematic species helps to reduce negative API & excipient interactions, maintaining both the stability of the drug and the final formulation. In addition, the removal of these impurities can minimise cellular irritation, reduce taste impact, and potentially decrease allergenicity.
We have a large variety of products, ranging from various polysorbates, polyethylene glycols (PEG), esters, vegetable oils, and more.
Tell me more
We have a large variety of products, ranging from various polysorbates, polyethylene glycols (PEG), esters, vegetable oils, and more.
Our Super Refined products offer…
