Avanti™ DOPC

1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or 18:1 (Δ9-Cis) PC (DOPC)

A highly unsaturated phospholipid that features 18-carbon acyl chains with a cis-double bond at the ninth position. This phospholipid has a low phase transition temperature of around –17°C, enabling it to remain in a fluid, liquid crystalline state at physiological temperatures. This feature makes it an essential lipid in liposomal drug delivery, cell membrane research, and biophysical studies.

DOPC, also known as 18:1 (Δ9-Cis) PC, is a phospholipid that contains unsaturated oleic acid (18:1) at the sn-1 and sn-2 positions. DOPC is a neutral helper lipid that has been shown to promote more stable laminar structures in LNPs and other drug delivery systems. Phosphatidylcholines (PCs), also referred to as neutral lipids, form the exterior layer of the delivery system.

Widely utilised in drug delivery systems, DOPC ensures optimal membrane fluidity, stability, and bioavailability in liposomal and lipid nanoparticle platforms. Research has shown it to be a major component of biological membrane models; it supports membrane dynamics and protein-lipid interaction studies.

Additionally, 18:1 (Δ9-Cis) PC (DOPC) is pivotal in LNP-based delivery technologies as a key phospholipid in siRNA, mRNA, and DNA vaccine formulations. Because of its unique lipid crystalline properties, it is also a widely used option for phase behavior research, lipid raft studies, and vesicle fusion experiments.