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Sustainably Sourced Squalene

Vaccines save lives. They keep schools open, and families connected. A key component in emulsion adjuvants in human vaccines is squalene. These adjuvant formulations induce a strong innate immune response and are characterised by an established safety profile and high tolerance in vulnerable people. 

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Sustainably sourced squalene from Croda Pharma

Squalene that swims above the rest. By staying out of the sea.

For decades, much of the world’s squalene supply for vaccines has come from shark livers, a practice that threatens biodiversity and leaves pharma supply chains open to risk. Croda’s Sustainably Sourced Squalene is based on cutting-edge technology using synthetic biology to obtain squalene from a fermentation process. Purification expertise and manufacturing excellence lead to a pharmaceutical grade squalene suitable for vaccine formulations.
Sustainably sourced Squalene from Croda Pharma

The right squalene keeps vaccines stable and the oceans wilder!

Our Sustainably Sourced Squalene is molecularly identical with shark-derived squalane. It remains stable after over 12 months of testing at various temperatures, allowing for cost-effective shipping and storage at ambient conditions. 

Squalene that proves itself at every stage.

All specification limits required by the Ph. Eur. monograph 2805 for squalene adjuvant in vaccines are met by our highly purified squalene. Its purity exceeds the minimum requirements of the Ph. Eur. monograph with a purity of at least 99% and meets the stringent requirements of the vaccine industry.  

Our Sustainably Sourced Squalene is available in GMP quality for vaccine manufacturing. 

Sustainably sourced and sustainable for the supply chain.

This production process ensures a scalable and reliable supply chain while helping to protect shark populations, which play a vital role in maintaining healthy marine ecosystems. 

Comprehensive data on the product carbon footprint and the use of natural resources are gladly provided upon request. 

Squalene-based emulsions are used in licensed seasonal and pandemic influenza vaccines. Moreover, there are ongoing clinical development projects for prophylactic vaccines—such as those against tuberculosis, shingles, schistosomiasis, HIV, and other severe diseases—that combine squalene with a TLR4 agonist in their emulsion adjuvant. 

Find more information like this in our Frequently Asked Questions here.

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Sustainably Sourced Squalene Featured

Sustainably Sourced Squalene

Our Sustainably Sourced Squalene is based on cutting-edge technology using synthetic biology to obtain squalene from a fermentation process.

Non-shark derived, sustainably sourced Squalene

The squalene market is moving towards more sustainable solutions, helping contribute to global efforts to protect the planet

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Superior purity

Our Squalene stands out on the market. It is at least 99% pure in line with stringent requirements of vaccine manufacturers
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More robust and scalable supply chain

The use of sustainably sourced Squalene helps us make progress towards a nature-positive supply chain
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High-performing alternative

Demonstrated stability of emulsion adjuvants, with our non-shark derived Squalene
Learn more about how you can benefit from the supreme purity of our Squalene. Contact us today to start the discussion.
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A history of supporting vaccines

As a key player in adjuvant development since 1939, our adjuvants have consistently been featured in countless peer-reviewed papers. Our leading R&D capabilities demonstrate our determination to advance drug delivery systems and novel vaccine adjuvants to tackle even more pathogens.
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Dedicated to your vaccine success

Developing and manufacturing vaccines is a costly challenge. Our team of experts are committed to helping you choose the right adjuvant for your needs. Save time and money by leveraging our decades worth of experience.

Frequently asked questions

Download Croda Pharmas newest whitepaper: Vaccines for a more sustainable future

Vaccines for a more sustainable future

EXCLUSIVE WHITEPAPER

The vaccines of tomorrow revolve around sustainable supply chains and access to scalable commercial supplies that do not put undue pressure on the natural environment. It is our responsibility to future-proof vaccines by focusing on longevity in our processes. With combined global efforts, we can enhance the global health infrastructure, leading us to develop better vaccines against more diseases and supporting our preparedness for future outbreaks.

We believe that global collaborations are the cornerstone of creating a greener planet. Let's do all we can today, to generate a sustainable future we're proud of.

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