Super Refined™ excipients for topical drug delivery
Common issues affecting topical formulation include active pharmaceutical ingredient (API) instability, poor API solubilisation, and skin irritation that can lead to reduced patient compliance. Our Super Refined excipients address these formulation concerns and maximise the value of your topical drug product.
High purity excipients for topical drug delivery
Our proprietary Super Refining process yields highly purified excipients that can maximise drug product value and are indicated to stabilise, solubilise and optimise the active ingredients in the formulation.
Maximising API stability
To demonstrate enhanced API stability, we monitored the percentage of the API lidocaine that could be recovered over time when incorporated into Super Refined Crodamol™ OO (oleyl oleate) versus standard compendial oleyl oleate. It can be seen that lidocaine maintains its integrity and stability far better in Super Refined Crodamol OO, with significantly less API being recovered from standard compendial grade oleyl oleate.
Maximising oxidative stability
To demonstrate oxidative stability, the peroxide value of Super Refined Crodamol OO was compared to standard compendial grade oleyl oleate over a 40 day study in accelerated ageing temperatures. It was noted that the Super Refined excipient maintained a low peroxide value while the standard compendial grade exhibited an approximate 70-fold increase in peroxide value, indicating that it has undergone significant primary oxidation.
Your partner for topical formulations
The efficacy of our dermatological ingredients is demonstrated by clinical studies across a range of therapies including skin hydration and barrier repair applications, emollient therapy and wound healing.
Super Refined™ pharmaceutical excipients
Explore some of our pharmaceutical excipients:
7 items available
-
Cithrol™ GMS 40 pharma
Nonionic emulsifier, W/O and O/W emulsion stabiliser, dispersant and emollient used in oral and topical pharmaceutical preparations as well as food applications. Used to form sustained release matrices...
-
Crodasol™ HS HP
Crodasol HS HP is a high purity nonionic surfactant which provides excellent solubilisation properties. Compliant to the PhEur monograph, it is a mixture of monoesters and diesters of 12-hydroxystearic...
-
Liquid Medilan™ Ultra
A Super Refined ultra-pure lanolin oil clinically proven to reduce the signs and symptoms of very dry, cracked skin. Offers superior aesthetic properties as an emollient and excipient in creams, lotions...
-
Medilan™ Super
Manufactured using Croda's patented Super Refining process to deliver a medical grade product with superior aesthetics. This product is suited to compromised skin conditions such as eczema and psoriasis....
-
Medilan™ Ultra
An ultra-pure grade of medical lanolin with barrier repair and wound healing properties. Its exceptional aesthetic properties and low drag make it particularly suitable for dermatological applications....
-
Span™ 20 HP
A high purity version of Span 20 tested against the USP/NF, PhEur and JPE monographs. This HP grade offers lower moisture levels as well as lower peroxide and acid values. Recommended use level is 0....
-
Span™ 80 HP
A high purity version of Span 80 tested against both PhEur and USP monographs. This HP grade offers lower moisture levels as well as lower peroxide and acid values. Recommended topical usage levels of...
.jpg&mn=healthcare&w=768&xr=0&yr=0&xfp=6&yfp=6&hash=8AF5F237FD30BDE03402A7A6081D2B6119C138999FEC74AA)
.jpg&mn=healthcare&w=768&xr=0&yr=0&xfp=6&yfp=6&hash=6D12401F4AA35E340BCC88758915C76019C138999FEC74AA)
Eczema
Eczema is a group of inflammatory skin disorders characterised by itchiness, dryness, scaling, sensitivity, cracking, and inflammation. Our dermatological solutions are designed to address these symptoms in a range of convenient formulations.
Our star excipient: Medilan™ (Wool Fat PhEur; Modified Lanolin NF), approved by the British Skin Foundation
- Replenishes the skin’s essential lipids
- Repairs the natural skin barrier to reduce transepidermal water loss
- Excellent skin hydration properties
- Provides long lasting emollience.
Featured
Medilan™
Highly purified medical grade lanolin, with clinically proven safety and efficacy, designed for the treatment of severely compromised skin conditions. Long-lasting emollient, moisturiser and skin...
Arlamol™ PS11E pharma
Polar non-occlusive emollient that acts as an excellent solvent for a wide range of actives and as a coupling agent, allowing the compatibility of polar and non-polar oils. Excellent spreader and...
Baby skin
Baby skin has a delicate and fragile structure which easily becomes dry or irritated due to urine contact, laundry detergent residues and central heating and air conditioning. Formulating for baby skin requires mild, effective moisturising ingredients and a dosage form that is quick and easy to apply or use in the bath.Our star excipeint: Arlamol™ PS11E (Polyoxypropylene Stearyl Ether PhEur)
- Excellent polar solvent for a wide range of actives
- Non-occlusive emollient offering a velvety skin feel
- Enables compatibility of polar and non-polar oils, making it possible to couple two actives into one product
- Produces liquid crystal oleosomes when used with Brij S2, Brij S721 and Crodacol CS90. Oleosome systems enable longer lasting skin hydration, pH flexibility, and increased salt tolerance and stability.
Acne
Formulating acne products requires light, non-occlusive ingredients to soothe inflamed skin, optimise the performance of anti-acne actives and encourage repeat use of the product.
Our star excipient: Super Refined™ Arlasolve™ DMI (Dimethyl Isosorbide)
- High purity, clear liquid epidermal penetration enhancer
- Excellent solubiliser
- Improves formulation and API stability
- Enhances spreading properties.
Super Refined™ DMI
High purity liquid for use with poorly soluble hydrophilic and hydrophobic actives. Enhances the formulation and API stability in transdermal delivery systems. Recommended topical usage levels of...
Super Refined™ excipients
We have a large variety of products, ranging from various polysorbates, polyethylene glycols (PEG), esters, vegetable oils, and more.
