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Dr Diego de Miguel

Dr Diego de MiguelDr. Diego de Miguel leads the Lipid Nanoparticle (LNP) Formulation Department at Certest Pharma, where he designs next-generation LNP platforms that broaden the therapeutic potential of mRNA vaccines and other nucleic-acid medicines. His formulation team is developing new lipid compositions that incorporate Certest’s proprietary ionizable lipids, improving the thermostability of LNPs through novel freeze-drying processes, and enhancing delivery precision with breakthrough passive and active targeting technologies.

Dr de Miguel earned his PhD in 2015 for work that leveraged lipid nanoparticles to deliver death ligands and chemotherapeutic drugs to cancer and immune cells. He then joined Professor Henning Walczak at the UCL Cancer Institute in London, where he focused on the molecular dissection of programmed cell-death and pro-inflammatory pathways. Upon returning to Spain, he applied his expertise in cell death and inflammation to translational models, advancing knowledge of natural-killer- and T-cell cytotoxic mechanisms to enhance immunotherapy by harnessing pro-inflammatory modes of cell death.

Since 2021, Dr de Miguel has combined deep cellular mechanistic insight with formulation know-how to accelerate Certest’s pipeline of thermostable, tissue-targeted LNPs. His cross-disciplinary background in immunology, cell biology and nanotechnology positions him at the forefront of delivering safer, more effective genetic medicines.