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GMP grade phospholipids for Nucleic Acid Delivery

Phospholipids are essential components of lipid nanoparticles (LNPs) following their long history of use in liposomal drug formulations.

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Phospholipids drive the formation of encapsulation, provide structure, and prevent the premature breakdown of LNPs. Recent studies have found that tuning the phospholipid component of an LNP can enhance delivery of nucleic acids by increasing endosomal escape in the case of phosphoethanolamine species; whereas, zwitterionic phospholipids may aid in the solubilization of nucleic acids inside the LNP1.

Explore our cGMP PEG offering: 

DOPC lipid nanoparticle structure


DOPC, also known as 18:1 (Δ9-Cis) PC, is a phospholipid that contains unsaturated oleic acid (18:1) at the sn-1 and sn-2 positions. DOPC is a neutral helper lipid that has been shown to promote more stable laminar structures in LNPs and other drug delivery systems.

DSPC lipid nanoparticle structure


DOPE, also known as 18:1 (Δ9-Cis) PE, is a phospholipid that contains unsaturated oleic acid at the sn-1 and sn-2 positions, a melting temperature of ~30 °C and a conical shape. DOPE tends to adopt an inverted hexagonal H(II) phase, which destabilizes endosomal membranes and facilitates endosomal escape of lipid nanoparticles.

DSPC lipid nanoparticle structure


DSPC, also known as 18:0 PC, is a phospholipid that contains saturated stearic acid at the sn-1 and sn-2 position. DSPC is the most common phospholipid used in lipid nanoparticles (LNP) due to its high transition temperature (55C) which works to prevent the premature breakdown of the LNP in biological systems.

Explore other GMP lipids:

Nucleic acid

Cationic lipids

Nucleic acid


Nucleic acid

Functional lipids

Nucleic acid


Nucleic acid

PEG lipids

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Why partner with us?

Support from concept to commercial

It starts with having the leading lipid technology experts in synthesis and formulation and approaching the discovery process in a collaborative nature, then having the expertise to transfer those learnings into a GMP manufacturing environment to support clinical development. And finally, having the commercial production capability to support launch and commercial supply.

Our full range of services include process chemistry, scale-up manufacturing, supply chain management with analytical and regulatory requirements. Our experienced staff of chemists and lipid analysts are ready to meet your development needs with pre-clinical through phase III and commercial launch, speak to one of our experts today!

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Lipid supporting services

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CDMO cGMP manufacturing

CDMO project management from R&D through to commercialization. Contract manufacturing of proprietary lipid products.
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Custom synthesis

Synthesis of research use materials for a variety of applications. Custom synthesis of reference standards or impurities.
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Development of a suitable formulation for lipid-based delivery systems. Custom lipid blends for use in delivery or diagnostic applications.