Phospholipids
Phospholipids drive the formation of encapsulation, provide structure, and prevent the premature breakdown of LNPs. Recent studies have found that tuning the phospholipid component of an LNP can enhance delivery of nucleic acids by increasing endosomal escape in the case of phosphoethanolamine species; whereas, zwitterionic phospholipids may aid in the solubilization of nucleic acids inside the LNP1.
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DOPE (18:1 PE)
DOPE, also known as 18:1 (Δ9-Cis) PE, is a phospholipid that contains unsaturated oleic acid at the sn-1 and sn-2 positions, a melting temperature of ~30 °C and a conical shape
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DOPC (18:1 PC)
DOPC, also known as 18:1 (Δ9-Cis) PC, is a phospholipid that contains unsaturated oleic acid (18:1) at the sn-1 and sn-2 positions. DOPC is a neutral helper lipid that has been shown to promote more...
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DSPC (18:0 PC)
Explore DSPC - Lipids systems are a versatile option for delivering hydrophobic, hydrophilic and amphipathic APIs.
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1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113778/