High purity excipients for topical drug delivery

Super Refined™ excipients for topical drug delivery

Common issues affecting topical formulation include active pharmaceutical ingredient (API) instability, poor API solubilisation, and skin irritation that can lead to reduced patient compliance. Our Super Refined excipients address these formulation concerns and maximise the value of your topical drug product.

High purity excipients for topical drug delivery

Our proprietary Super Refining process yields highly purified excipients that can maximise drug product value and are indicated to stabilise, solubilise and optimise the active ingredients in the formulation.

Maximising API stability 

To demonstrate enhanced API stability, we monitored the percentage of the API lidocaine that could be recovered over time when incorporated into Super Refined Crodamol™ OO (oleyl oleate) versus standard compendial oleyl oleate. It can be seen that lidocaine maintains its integrity and stability far better in Super Refined Crodamol OO, with significantly less API being recovered from standard compendial grade oleyl oleate.

Maximising oxidative stability 

To demonstrate oxidative stability, the peroxide value of Super Refined Crodamol OO was compared to standard compendial grade oleyl oleate over a 40 day study in accelerated ageing temperatures. It was noted that the Super Refined excipient maintained a low peroxide value while the standard compendial grade exhibited an approximate 70-fold increase in peroxide value, indicating that it has undergone significant primary oxidation.

Eczema

Eczema is a group of inflammatory skin disorders characterised by itchiness, dryness, scaling, sensitivity, cracking, and inflammation. Our dermatological solutions are designed to address these symptoms in a range of convenient formulations.

Our star excipient: Medilan™ (Wool Fat PhEur; Modified Lanolin NF), approved by the British Skin Foundation

• Replenishes the skin’s essential lipids
• Repairs the natural skin barrier to reduce transepidermal water loss
• Excellent skin hydration properties
• Provides long lasting emollience.

Baby skin

Our star excipeint: Arlamol™ PS11E (Polyoxypropylene Stearyl Ether PhEur)

• Excellent polar solvent for a wide range of actives
• Non-occlusive emollient offering a velvety skin feel
• Enables compatibility of polar and non-polar oils, making it possible to couple two actives into one product
• Produces liquid crystal oleosomes when used with Brij S2, Brij S721 and Crodacol CS90. Oleosome systems enable longer lasting skin hydration, pH flexibility, and increased salt tolerance and stability.

Acne

Formulating acne products requires light, non-occlusive ingredients to soothe inflamed skin, optimise the performance of anti-acne actives and encourage repeat use of the product.

Our star excipient: Super Refined™ Arlasolve™ DMI (Dimethyl Isosorbide)

• High purity, clear liquid epidermal penetration enhancer
• Excellent solubiliser
• Improves formulation and API stability
• Enhances spreading properties.