Polysorbates and beyond: Optimising surfactant strategy in biologic drug formulation

Leveraging the industry’s broadest surfactant toolbox

Biologic formulations face inherent challenges such as protein unfolding, aggregation, as well as mechanical stress, all of which can compromise stability and therapeutic performance. Surfactants such as polysorbates, poloxamer 188, and others play a key role as critical functional excipients in mitigating these risks and ensuring formulation integrity. Yet, identifying the right excipients for biologic drug formulations requires careful consideration of multiple, interdependent factors.
 
Our technical experts will explore new insights on surfactant selection strategies for biotherapeutics, guided by three key pillars:

• Deepening our understanding of polysorbates to de-risk their use
• Exploring and benchmarking alternative options with minimal regulatory hurdles
• Searching for novel opportunities in surfactants for biotherapeutics

In this webinar, we’ll present never-before-seen stability data for both model and real biotherapeutic proteins across various surfactant chemistries, including polysorbates, poloxamers, and more from Croda’s Super Refined™ and HP product ranges. We will also examine chemical and enzymatic degradation, excipient-protein interactions, and long-term protein stability as we weigh the pros and cons of formulating with different surfactant options. Join us as we explore how Croda’s broad surfactant portfolio enables tailored solutions that enhance protein stability and unlock exceptional biologic formulation performance.