Solutions for biologic formulations

Bioprocessing solutions
Our solutions for bioprocessing now include ingredients for cell culture, as well as sustainable, compendial detergents for viral inactivation and cell lysis, meeting the needs of end-applications such as the biomanufacture of recombinant protein therapeutics, viral vector-based therapies, plasma-derived or blood fractionation therapies, and more.  

• Virodex™ range: Sustainable, compendial, cGMP, REACH compliant detergents for viral inactivation and cell lysis  
• Super Refined™ Poloxamer 188: Highly purified poloxamer 188, optimised for mammalian cell culture with exceptional batch-to-batch consistency
• High purity bioprocessing ingredients: A range of GMP and high purity solutions, including Super Refined Polysorbates and Super Refined Benzyl Alcohol

Adjuvant Systems - Leading source of next-generation adjuvants
Our unique GMP portfolio and outstanding expertise can meet your adjuvant needs. Collaborate with our scientists to create the vaccines of tomorrow.

• Sustainable squalene: Our Sustainable Squalene is based on cutting-edge technology using synthetic biology to obtain squalene from a fermentation process. The final purification step turns it into a pharmaceutical grade Squalene suitable for vaccine formulations. It is molecularly identical to shark-derived squalene with demonstrated stability in emulsion adjuvants.
• Mineral adjuvants: Alhydrogel™ | Adju-Phos™
• Liposomal adjuvants: CAF®01 | CAF®09b
• Saponin adjuvants: QS-21 | NanoQuil™
• TLR4 agonists: PHAD™ |  3D-PHAD™  |  3D-(6-acyl)-PHAD™
• Other components: Plant-based cholesterol

Lipids from concept to commercial
Whatever your requirement our extensive portfolio can meet your needs, we offer both research grade materials and GMP grade lipids for your discovery, clinical and commercial manufacturing requirements. Our GMP grade lipids for Nucleic Acid Delivery include:

• Cationic lipids
• PEG lipids
• Functionalised lipids
• Phospholipids
• Sterols

Lipid supporting services

• CDMO cGMP manufacturing: CDMO project management from R&D through to commercialization. Contract manufacturing of proprietary lipid products
• Custom synthesis: Synthesis of research use materials for a variety of applications. Custom synthesis of reference standards or impurities
• Formulation: Development of a suitable formulation for lipid-based delivery systems. Custom lipid blends for use in delivery or diagnostic applications

Download the respective materials to learn more!

For more information, please contact your local representative Roberta Ondei at Roberta.Ondei@croda.com