Avanti™ DSG PEG2000

distearoyl-rac-glycerol-PEG2K

Avanti™ DSG-PEG 2000 (distearoyl-rac-glycerol-PEG2K) is a non-ionic, PEGylated lipid that serves as a steric‐stabilizing excipient in lipid-based formulations (e.g., liposomes, lipid nanoparticles), contributing to surface stabilization and prolonged circulation by reducing non-specific interactions.

The DSG-PEG 2000 product is composed of a hydrophobic distearoyl-rac-glycerol anchor covalently linked to a hydrophilic polyethylene glycol (PEG 2000) chain, enabling the DSG moiety to embed in the lipid bilayer while the PEG segment extends outward to form a hydrated, neutral surface layer. This structure minimizes non-specific interactions, enhances colloidal stability, and supports prolonged circulation and predictable particle behavior in biological systems.

Applications

DSG-PEG 2000 is used as a surface-stabilizing excipient in research involving:

• Lipid nanoparticle (LNP) and liposome preparation for small interfering RNA (siRNA) delivery research
• Nanocarrier-based delivery of nucleic acids, peptides, or small molecules
• Formulations requiring reduced aggregation during preparation or storage (e.g., lipid dispersions, colloidal suspensions)
• Systems where a neutral, steric barrier is needed to modulate surface interactions

Because the molecule is non-ionic, it is often selected when charge neutrality and minimized protein binding are desired.