We can't wait to see you at TIDES!
Each year, the TIDES conference scientific agenda includes 150+ of the industry's top scientists to present the latest science and industry updates across the entire spectrum from discovery, preclinical, clinical development through CMC, manufacturing and commercialization of therapeutics and vaccines for oligos, peptides, mRNA and genome editing products. We will be available to discuss your projects and answer questions! We're always here to help. We can't wait to see you in San Diego, CA, May 7th-10th!
Curious about our innovative lipids and their ability to fuel your drug delivery research?
For over 30 years, Avanti have been working with the pharmaceutical and diagnostic industry to provide solutions that save or improve lives. We were integrally involved in the development of liposomal-based drug delivery systems and over the past decade, we have concentrated on developing lipid components used in Lipid Nanoparticle (LNP) delivery technology to solve the stability and delivery issues associated with mRNA-based vaccines and therapeutics.
LNPs are lipid-based drug delivery systems that carry nucleic acid material. These systems primarily rely on four lipid components: a PEG lipid, amino (cationic) lipid, structural lipid, and cholesterol.
The cationic lipids are used to sequester the genetic material through a charge-charge interaction. This is encapsulated by the structural lipid and functionalized on the exterior with PEG lipids. Genetic material is highly susceptible to RNAse activity but the LNP protects the genetic material from degradation. The LNP also allows the genetic material to access the cell and, once inside, be released. This allows the cellular machinery to translate the delivered genetic material into a cellular response.
When conducting LNP formulation research there are many important factors to consider including size and shape, surface charge, hydrophobicity, and surface functionalization. Avanti offers a wide variety of cGMP manufactured lipids that will allow you to perfectly tailor your drug delivery systems. As always, these lipids are manufactured to meet the highest purity standards ensuring targeted, controlled, and extended-release of active pharmaceutical ingredients, increasing efficacy and safety.
If you have a lipid-based drug delivery problem that needs to be solved, reach out to us! We can help you with:
- The supply of GMP lipids for your lipid nanoparticle formulation
- Contract manufacturing of proprietary lipids
- Formulation development and manufacturing.
Nobody surpasses our quality or dedication to finding solutions for lipid-based problems. Avanti have supplied lipids for commercial drug product manufacturing for over 30 years and we are here to help you too!