Avanti™ DSPE-PEG2000 Amine

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt)

DSPE-PEG(2000) Amine from Avanti™ is a (PEG) 2000-modified, DSPE-anchored phospholipid bearing a terminal primary amine, enabling versatile formulation conjugation strategies and surface functionalization of liposomes or lipid nanoparticles for drug delivery research.

The hydrophobic DSPE tail anchors the molecule within lipid bilayers, ensuring stable incorporation into liposomes or lipid nanoparticles, while the polyethylene glycol (PEG) polymer spacer chain provides hydrophilicity, steric stabilization, and increases its solubility when dispersed in aqueous media.

The amine end group serves as a reactive handle for coupling to activated esters, dyes, linkers, or targeting ligands, making this DSPE-PEG conjugate a versatile helper lipid for custom nanoparticle surface modification and supporting diverse bioconjugation workflows.

Applications

Labs researching and developing lipid-based drug delivery systems use Avanti Research™ DSPE-PEG(2000) Amine to introduce reactive amine groups onto the surface of liposomes, lipid nanoparticles, and related nanocarriers.

Once incorporated, the primary amine can be coupled to a wide range of molecules, supporting custom conjugation chemistry specific to the needs of the research system. This includes:

• Peptides, proteins, or affinity tags
• Fluorescent or imaging labels
• Crosslinkers, polymers, or linker scaffolds
• Preparation of targeted or imaging-enabled nanocarriers for binding or recognition studies