ALC-0315

6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium, or ALC-0315, is a highly specialized ionizable lipid engineered for LNP drug delivery systems. As a critical component in mRNA-based vaccines and gene therapies, it plays a significant role in nucleic acid encapsulation, intracellular delivery, and endosomal escape.

ALC-0315 is a cornerstone of modern RNA-based medicine, designed to optimize the stability and bioavailability of mRNA, siRNA, and CRISPR-based therapeutics.

ALC-0315 is a fundamental LNP component in mRNA-based vaccines used to ensure efficient payload protection and delivery. ALC-0315 also enables targeted nucleic acid delivery with low toxicity and high transfection efficiency crucial for RNA therapeutics.

This cationic lipid also enhances CRISPR, siRNA, and antisense oligonucleotide transport to facilitate precise gene modulation. Additionally, it is driving the development of next-generation RNA therapeutics by supporting advancements in oncology, rare disease treatment, and personalized medicine.

ALC-0315 is an ionizable cationic lipid used in combination with other lipids to form lipid nanoparticles (LNPs). Cationic lipids are used to complex negatively charged nucleic acid cargo and make up the center of an LNP delivery system.