Avanti™ DMPG

14:0 PG or 1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol), sodium salt (DMPG) is a form of phosphoglyceride (PG), a minor component (only one to two percent) of most cell membranes. Phosphoglyceride (PG), also known as glycerophospholipid, forms an essential component of membrane bilayers, including up to 20 percent of bacterial membranes across diverse biological systems.

14:0 PG is integral to cellular membranes, with its unique structure consisting of a three-carbon glycerol backbone, two long-chain fatty acids, esterified to hydroxyl groups on carbons 1 and 2 of the glycerol, and phosphoric acid esterified to the C3 hydroxyl group of glycerol. PG is abundant in all cell membranes and is present in minimal quantities in fat reserves. It's used by cells as part of the transition to cardiolipin synthesis.

Additionally, PG can be detected at higher concentrations (up to 11 percent of the total lipid content) within lung surfactants. Its presence in amniotic fluid serves as an indicator of fetal lung maturity and forms the foundation of clinical testing for fetal fitness.

This phospholipid serves various research purposes, including preparing lipid bicelles for nuclear magnetic resonance (NMR) experiments and facilitating detailed structural analyses. Additionally, it can be used as a phospholipid (PL) standard for accurately quantifying phosphatidylglycerol via chromatography to ensure precise measurements. Furthermore, researchers utilize 14:0 PG in crafting DMPG (l-dimyristoylphosphatidylglycerol) phospholipid vesicles, enabling the investigation of the inner workings of cell membranes.

Lipids systems are a versatile option for delivering hydrophobic, hydrophilic and amphipathic APIs. Our offering of Phosphatidylcholine, Phosphatidylethanolamine, Phosphatidylserine, and Phosphatidylglycerol lipids is designed to provide compounds having a variety of physical properties for a broad range of delivery systems.