3D(6-acyl)-PHAD™

Immunostimulatory and highly purified, 3D(6-acyl)-PHAD activates TLR4 to induce proinflammatory cytokines and T-cells.

3D(6-acyl)-PHAD is a synthetically produced structural analogue of monophosphoryl lipid A (MPLA), which is originally derived from Salmonella minnesota.

As part of our PHAD portfolio, 3D(6-acyl)-PHAD has a unique chemical structure that consists of a hexapeptide modified with a pyridoxal-phosphate group and a fatty acid chain.

Research has shown that it can, like MPLA, stimulate the immune system by activating immune cells such as dendritic cells and macrophages. These cells are important for processing and presenting antigens to other immune cells, and their activation can lead to an enhanced immune response.

3D(6-acyl)-PHAD has notable advantages for adjuvant systems. It has a strong immunostimulatory effect when combined with antigens from different pathogens. Specifically, it can increase the antibody response and elicit cellular Th1-type immune responses. This makes it a potential adjuvant candidate in vaccine development.

To date, 3D(6-acyl)-PHAD has been used in vaccine research for renal cell carcinoma, human papillomaviruses, and hepatitis B virus.

Determining what immunostimulator is best suited to your needs requires a discussion. Contact us to start your journey today.