Super Refined™ products for oral formulations
Our Super Refined™ technology produces high-purity excipients, which provide several benefits in a formulation for oral products. These benefits include:
- Increased stability of the product
- Improved stability in gelatin capsules
- Less impact of taste, odour and colour.
As a result, they optimise the bioavailability of the product and its shelf life, increase patient compliance and reduce the development, decreasing the time to market.
Super Refined Excipients for Oral Drug Delivery
How we mitigate the taste of excipients in oral formulations
Super Refined excipients have minimal taste compared to their standard pharmaceutical equivalent grades, resulting in more palatable patient medicines. To demonstrate this, our Super Refined excipients and their standard pharmaceutical equivalent grades were tested by a panel of trained taste specialists (Sensory Spectrum, Inc.) to quantitatively identify the degree of difference in taste. The Degree of Difference (DOD) scores ranged from 0-10, with 0 indicating no difference and 10 indicating an extreme difference. A DOD of 5 or higher indicates that consumers will be able to perceive a difference in taste, while a DOD of 4-5 indicates a consumer might perceive a difference in taste.
The chart shows that the DOD between Super Refined Polysorbate 80 and its Polysorbate 80 NF benchmark was assigned as 8, indicating that Super Refined Polysorbate 80 has a consumer perceivable taste difference compared to its compendial grade. This has also been shown to be the case with other Super Refined excipients, supporting their use in formulating more palatable oral liquid dosage forms in order to improve patient compliance and outcomes.
Discover our Super Refined™ range
SEDDS e SMEDDS
Os sistemas de SEDSS e SMEDDS são misturas de óleos, surfactantes, solventes e substância fármacos que rápida e espontaneamente refinam emulsões ou microemulsões óleo-em-água quando introduzidos em fases aquosas sob agitação suave.
Saiba maisSolventes Farmacêuticos
Alcançar a solubilidade do IFA é um dos grandes desafios enfrentados pelos formuladores, com muitos APIs tendo baixa solubilidade. Nossa linha de solventes farmacêuticos Super Refined™ pode enfrentar esse desafio, fornecendo uma variedade de solventes polares e não polares que não apenas fornecem solubilidade, mas também excelente estabilidade para IFAs.
Saiba maisGuia de Solubilidade Farmacêutica
Como a solubilidade do API continua a apresentar desafios para o formulador farmacêutico, a Croda determinou a solubilidade de uma gama de ativos em uma série de excipientes de alta pureza da Croda.
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