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GMP grade functionalised lipids for Nucleic Acid Delivery

Liposomes and lipid nanoparticles are commonly used drug delivery systems. In recent years, bioconjugation strategies focused on formulations using functionalised lipids to improve drug loading and targeting has been at the forefront for advancement of the field.

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Functionalised lipids

Covalently linking drugs to PEGylated lipids containing disulfide, ester, carboxy, hydrazone, and other functional groups has been found to be a viable strategy to control drug loading and release. In addition, lipids functionalised with maleimide, NHS esters, DBCO, and others can be used enhance the lipid delivery system’s ability to deliver drug payloads to the intended therapeutic target through bioconjugation of antibodies, aptamers, peptides, proteins, and enzymes. 

As innovation occurs in delivery formulations, Avanti is the perfect partner to supply the lipids to make your project a success! Our team of formulation and lipid synthesis experts are here to innovate with you and tackle challenges head on. Can’t find your perfect functionalised lipid? Contact our custom synthesis team today!

Nucleic acid

DSPE-PEG(2000) Carboxy

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt)

Explore other GMP lipids:

Nucleic acid

Cationic lipids

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Nucleic acid

Phospholipids

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Nucleic acid

Sterols

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Nucleic acid

Polysorbates

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Nucleic acid

PEG lipids

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Smart science to improve lives™

Seu parceiro de soluções farmacêuticas:

Excipientes de alta pureza: Otimizando a performance de formulações para solucionar problemas relacionados a estabilidade e solubilidade

Adjuvantes de vacinas: Comprometidos com os mais altos padrões de qualidade, com mais de 80 anos de experiência em pesquisa e desenvolvimento de adjuvantes

Lipídios inovadores: Permitindo a entrega e estabilidade de vacinas baseadas em ácido nucleico e tecnologias terapêuticas e de edição genética.

Estamos determinados a impulsionar a próxima geração de Drug Delivery Systems. Ao se associar à Croda Pharma, você contará com uma equipe altamente preparada para atender às demandas mais requisitadas da indústria farmacêutica.

Lipid supporting services

CDMO cGMP manufacturing

CDMO project management from R&D through to commercialization. Contract manufacturing of proprietary lipid products.

Custom synthesis

Synthesis of research use materials for a variety of applications. Custom synthesis of reference standards or impurities.

Formulation

Development of a suitable formulation for lipid-based delivery systems. Custom lipid blends for use in delivery or diagnostic applications.
Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730700/