Super Refined excipients for GLP-1 peptide therapeutics

Peptide therapeutics such as GLP-1 receptor agonists represent one of the fastest-growing segments of the pharmaceutical market. Peptides such as semaglutide, tirzepatide, and liraglutide are highly sensitive to impurities, including aldehydes, peroxides, and trace metals, which can accelerate degradation and compromise long-term stability. Croda’s Super Refined™ excipients are manufactured using proprietary purification processes that minimise reactive impurities and deliver consistent, tightly controlled impurity profiles. The following case studies demonstrate how excipient purity directly influences peptide stability across several commercially relevant peptides.