DOPE, also known as 18:1 (Δ9-Cis) PE, is a phospholipid that contains unsaturated oleic acid at the sn-1 and sn-2 positions, a melting temperature of ~30 °C and a conical shape. DOPE tends to adopt an inverted hexagonal H(II) phase, which destabilizes endosomal membranes and facilitates endosomal escape of lipid nanoparticles.
Detalles del producto
Grupo quimico
- Fosfolípidos
- Lípidos
Vía de administración
- Parenteral
Aplicación comercial
- API
- Producto farmacéutico humano
- Salud veterinaria
- Vacunas para uso humano
- Vacunas veterinarias
Funciones
- Excipiente