1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000
This product is a mixture of 1,2-DMG PEG2000 and 1,3-DMG PEG2000 in ~97:3 ratio. Representative Structure The molecular weight and exact mass are averages based on the polydispersity of PEG.
Polyethylene glycol (PEG)-lipids have been the polymer-lipid conjugate of choice for lipid formulations for decades. PEG-lipids are used increase systemic circulation times, mediate indirect targeting capabilities, promote LNP self-assembly, control size and aid in storage stability. Particles containing PEG-lipids are able to bypass the reticulo-endothelial system, giving them their nickname - “stealth agents”. The DMG lipid anchor has 2 saturated 14-carbon chains and an easily cleaved linker aiding in PEG shedding that will enable higher liver tropism when administered systemically.
Functions include:
- Increased half life when administered systemically
- Aids in storage ability
- Helps obtain small particle sizes
This product is a mixture of 1,2-DMG PEG2000 and 1,3-DMG PEG2000 in ~97:3 ratio. Representative Structure The molecular weight and exact mass are averages based on the polydispersity of PEG.
Polyethylene glycol (PEG)-lipids have been the polymer-lipid conjugate of choice for lipid formulations for decades. PEG-lipids are used increase systemic circulation times, mediate indirect targeting capabilities, promote LNP self-assembly, control size and aid in storage stability. Particles containing PEG-lipids are able to bypass the reticulo-endothelial system, giving them their nickname - “stealth agents”. The DMG lipid anchor has 2 saturated 14-carbon chains and an easily cleaved linker aiding in PEG shedding that will enable higher liver tropism when administered systemically.
Functions include:
- Increased half life when administered systemically
- Aids in storage ability
- Helps obtain small particle sizes